p-ISSN 2083-389x   e-ISSN 2084-3127

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NOVEL TRENDS IN THE MOLECULAR GENETICS OF HEARING LOSS

Urszula Lechowicz, Agnieszka Pollak, Monika Oldak

(Department of Genetics, World Hearing Center, Institute of Physiology and Pathology of Hearing, Warsaw/Kajetany, Poland)

JHS 2015; 5(3): 9-15

DOI: 10.17430/895541

Published: 2015-11-12


ABSTRACT: Genetically determined hearing loss is a highly heterogeneous disorder, and to date the analysis of its causes has been conducted selectively, covering only individual genes. Breakthroughs associated with current technological advances have contributed to a rapid development in the molecular genetics of hearing loss. Here we review a number of novel and important achievements in the field: application of next-generation sequencing, novel genes, and trends in molecular therapies for hearing loss. Current achievements in the molecular genetics of hearing loss are discussed in the context of previously published results and data from our own studies.

Keywords: Genetics, Hearing Loss, High-Throughput Nucleotide Sequencing, Molecular Biology



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