Current Issue
Volumes and Issues
For Authors
Manuscript Guidelines
Review Process
Conflict of Interest
Copyright
About the Journal
Editorial Board
Aim and Scope
Policy and Ethical Guidelines
Promotion of the Journal
Print-Version Subscription
Publisher and Contact Information
Contact Information
Sign in as an AUTHOR/REVIEWER
ORIGINAL ARTICLE
AUDITORY NEUROPATHY SPECTRUM DISORDER IN CHILDREN: ASSOCIATION BETWEEN PERINATAL RISK FACTORS AND RADIOLOGY
1
Department of Otolaryngology, Postgraduate Institute of Medical Education and Research, India
2
Department of Otolaryngology, Speech and Hearing Unit, Post Graduate Institute of Medical Education and Research, India
3
Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, India
4
Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, India
A - Research concept and design; B - Collection and/or assembly of data; C - Data analysis and interpretation; D - Writing the article; E - Critical revision of the article; F - Final approval of article;
Submission date: 2021-09-05
Final revision date: 2022-06-09
Acceptance date: 2022-11-15
Online publication date: 2022-12-29
Publication date: 2022-12-29
Corresponding author
Anuradha Sharma
Department of Otolaryngology, Speech and Hearing Unit, Post Graduate Institute of Medical Education and Research, New Opd, Pgimer, 160014, sector 12, India
Department of Otolaryngology, Speech and Hearing Unit, Post Graduate Institute of Medical Education and Research, New Opd, Pgimer, 160014, sector 12, India
J Hear Sci 2022;12(4):32-38
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Radiological assessment plays a vital role in identifying auditory neuropathy spectrum disorder (ANSD) in children. Identifying the neonatal risk factors and their association with radiological findings might facilitate the management of children with ANSD. The goal of the current work was to investigate the relationship between perinatal risk factors and radiological findings in children with ANSD.
Material and methods:
Altogether, 28 children with ANSD aged 1 to 6 were enrolled. Behavioural observation audiometry (BOA), otoacoustic emissions (OAEs), and auditory brainstem responses (ABRs) were conducted. High-resolution computed tomography (CT) and magnetic resonance imaging (MRI) were performed.
Results:
There was a statistically significant association between ANSD risk factors – hydrocephalus, preterm birth, hyperbilirubinemia, entry into newborn intensive care, and cerebral palsy – and white matter changes and cerebral/brainstem abnormalities.
Conclusions:
In children with ANSD, certain cerebral/brainstem abnormalities and white matter changes were associated with the condition. To minimize the impact of hearing loss, radiological assessments should be conducted on all children having ANSD risk factors.
Radiological assessment plays a vital role in identifying auditory neuropathy spectrum disorder (ANSD) in children. Identifying the neonatal risk factors and their association with radiological findings might facilitate the management of children with ANSD. The goal of the current work was to investigate the relationship between perinatal risk factors and radiological findings in children with ANSD.
Material and methods:
Altogether, 28 children with ANSD aged 1 to 6 were enrolled. Behavioural observation audiometry (BOA), otoacoustic emissions (OAEs), and auditory brainstem responses (ABRs) were conducted. High-resolution computed tomography (CT) and magnetic resonance imaging (MRI) were performed.
Results:
There was a statistically significant association between ANSD risk factors – hydrocephalus, preterm birth, hyperbilirubinemia, entry into newborn intensive care, and cerebral palsy – and white matter changes and cerebral/brainstem abnormalities.
Conclusions:
In children with ANSD, certain cerebral/brainstem abnormalities and white matter changes were associated with the condition. To minimize the impact of hearing loss, radiological assessments should be conducted on all children having ANSD risk factors.
REFERENCES (25)
1.
Berlin CI, Hood LJ, Morlet T, Rose K, Brashears S. Auditory neuropathy/dyssynchrony: diagnosis and management. Mental Retard Devel Disabil Res Reviews 2003; 9, 225–31.
2.
Starr A, Picton TW, Sininger Y, Hood LJ, Berlin CI. Auditory neuropathy. Brain, 1996; 119: 741–53.
3.
Rance G, Beer DE, Cone-Wesson B, Shepherd RK, Dowell RC, King AM, et al. Clinical findings for a group of infants and young children with auditory neuropathy. Ear Hear, 1999; 21: 238–52.
4.
Rapin I, Gravel J. Auditory neuropath: physiologic and pathologic evidence calls for more diagnostic specificity. Int J Pediatr Otorhinolaryngol, 2003; 67, 707–28.
5.
Fuchs PA, Glowatzki E, Moser T. The afferent synapse of cochlear hair cells. Curr Opin Neurobiol, 2003; 13: 452–8.
6.
Nikolopoulos TP. Auditory dyssynchrony or auditory neuropathy: understanding the pathophysiology and exploring methods of treatment. Int J Pediatr Otorhinolaryngol, 2014; 78(2): 171–3.
7.
James, AL, Osborn HA, Osman H, Papaioannou V, Gordon KA. The limitation of risk factors as a means of prognostication in auditory neuropathy spectrum disorder of perinatal onset. Int J Pediatr Otorhinolaryngol, 2020; 135: 110112.
8.
Rea PA, Gibson WP. Evidence for surviving outer hair cell function in congenitally deaf ears. Laryngoscope, 2003; 113(11): 2030–4.
9.
Sininger YS, Oba S. Patients with auditory neuropathy: who are they and what can they hear? In: Sininger YS, Starr A, editors. Auditory Neuropathy: A New Perspective on Hearing Disorders. San Diego: Singular Thomson Learning; 2001, 15–35.
10.
Akman I, Arika C, Bilgen H, Kalaca S, Ozek E. Transcutaneous measurement of bilirubin by icterometer during phototherapy on a bilibed. Turkish J Med Sci, 2000; 32: 165–8.
11.
Berg AL, Spitzer JB, Towers HM, Bartosiewicz C, Diamond BE. Newborn hearing screening in the NICU: profile of failed auditory brainstem response/passed otoacoustic emission. Pediatrics, 2005; 116: 933–8.
12.
Xoinis K, Weirather Y, Mavoori H, Shaha SH, Iwamoto LM. Extremely low birth weight infants are at high risk for auditory neuropathy. J Perinatol, 2007; 27, 718–23.
13.
Roche JP, Huang BY, Castillo M, Bassim MK, Adunka OF, Buchman CA. Imaging characteristics of children with auditory neuropathy spectrum disorder. Otol Neurotol, 2010 Jul; 31(5): 780–8.
14.
Skranes J, Vangberg TR, Kulseng S, Indredavik MS, Evensen KA, Martinussen M, et al. Clinical findings and white matter abnormalities seen on diffusion tensor imaging in adolescents with very low birth weight. Brain, 2007; 130 (Part 3); 654–66.
15.
Yilmaz Y, Alper G, Kilicoglu G, Celik L, Karadeniz L, Yilmaz-Degirmenci S. Magnetic resonance imaging findings in patients with severe neonatal indirect hyperbilirubinemia. J Child Neurol, 2001; 16(6): 452–5.
16.
Kim MH, Yoon JJ, Sher J, Brown AK. Lack of predictive indices in kernicterus: a comparison of clinical and pathological factors in infants with or without kernicterus. Pediatrics, 1980; 66(6): 852–8.
17.
Turkel SB, Miller CA, Guttenberg ME, Moynes DR, Hodgman JE. A clinical pathologic reappraisal of kernicterus. Pediatrics, 1982; 69: 267–72.
18.
Volpe JJ. Brain injury in the premature infant. Neuropathology, clinical aspects, pathogenesis, and prevention. Clin Perinatol, 1997; 24(3): 567–87.
19.
Volpe JJ. Neurobiology of periventricular leukomalacia in the premature infant. Pediatr Res, 2001; 50: 553–62.
20.
Olsen P, Vainionpaa L, Paakko E, Korkman M, Pyhtinen J, Jarvelin MR. Psychological findings in preterm children related to neurologic status and magnetic resonance imaging. Pediatrics, 1998; 102: 329–36.
21.
Inder TE, Huppi PS, Warfield S, Kikinis R, Zientara GP, Barnes PD, et al. Periventricular white matter injury in the premature infant is followed by reduced cerebral cortical grey matter volume at term. Ann Neurol, 1999; 46: 755–60.
22.
Ajayi-Obe M, Saeed N, Cowan FM, Rutherford MA, Edwards AD. Reduced development of cerebral cortex in extremely preterm infants. Lancet, 2000; 356: 1162–3.
23.
Peterson B. Brain imaging studies of the anatomical and functional consequences of preterm birth for human brain development. Ann NY Acad Sci, 2003; 1008: 219–37.
24.
Inder TE, Warfield SK, Wang H, Hüppi PS, Volpe JJ. Abnormal cerebral structure is present at term in premature infants. Pediatrics, 2005; 115: 286–94.
25.
Woodward LJ, Anderson PJ, Austin NC, Howard K, Inder TE. Neonatal MRI to predict neurodevelopmental outcomes in preterm infants. N Engl J Med, 2006; 355: 685–94.
Share
RELATED ARTICLE
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
