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ORIGINAL ARTICLE
CHANGES OF BLOOD COMPOSITION DURING GENTAMICIN INTOXICATION AND CORRECTION WITH PHOSPHOLIPIDS
1
Otolaryngology, Tashkent Medical Academy, Uzbekistan
A - Research concept and design; B - Collection and/or assembly of data; C - Data analysis and interpretation; D - Writing the article; E - Critical revision of the article; F - Final approval of article;
Publication date: 2021-12-03
Corresponding author
Akida Utkurovna Ibragimova
Otolaryngology, Tashkent Medical Academy, Farobiy 2, 100109, Tashkent, Uzbekistan
Otolaryngology, Tashkent Medical Academy, Farobiy 2, 100109, Tashkent, Uzbekistan
J Hear Sci 2021;11(3):38-42
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The purpose of this study was to determine the diagnostically significant laboratory parameters which are predictors of sensorineural hearing loss in the blood of children receiving gentamicin, and to develop ways of its correction.
Material and methods:
The study included 50 children who were hospitalized at the Republican Perinatal Center of the Tashkent Pediatric Medical Institute in need of antibiotic treatment. They had not recently received aminoglycoside antibiotics but anamnesis showed that these children had experienced their prolonged use. The patients were divided into 2 groups, as follows. Group 1 comprised children who were prescribed gentamicin as a course of treatment at an age-appropriate dose of 2–5 mg/kg, 2 times a day (n = 25). The second group consisted of 25 patients who were prescribed gentamicin with simultaneous administration of phosphogliv. A control group (n = 20) consisted of children who did not receive gentamicin.
Results:
Gentamycin-induced intoxication was determined by diagnostically significant laboratory criteria for neuron-sensitive deafness. It was found that phosphogliv, which contains essential phospholipids in complex with aminoglycosides, could prevent neuron-sensitive deafness in children. Accompanying the use of gentamicin and phosphogliv in the second group, there was a significant decrease in the average level of molecular peptides in the blood, and the concentration of malondialdehyde decreased 2.4 times relative to the first group (p < 0.05).
Conclusions:
Use of gentamicin with simultaneous essential phospholipids helps to reduce the amount of malondialdehyde in the blood, reduce medium-molecular peptides, and increase the activity of enzyme-protecting superoxide dismutase.
The purpose of this study was to determine the diagnostically significant laboratory parameters which are predictors of sensorineural hearing loss in the blood of children receiving gentamicin, and to develop ways of its correction.
Material and methods:
The study included 50 children who were hospitalized at the Republican Perinatal Center of the Tashkent Pediatric Medical Institute in need of antibiotic treatment. They had not recently received aminoglycoside antibiotics but anamnesis showed that these children had experienced their prolonged use. The patients were divided into 2 groups, as follows. Group 1 comprised children who were prescribed gentamicin as a course of treatment at an age-appropriate dose of 2–5 mg/kg, 2 times a day (n = 25). The second group consisted of 25 patients who were prescribed gentamicin with simultaneous administration of phosphogliv. A control group (n = 20) consisted of children who did not receive gentamicin.
Results:
Gentamycin-induced intoxication was determined by diagnostically significant laboratory criteria for neuron-sensitive deafness. It was found that phosphogliv, which contains essential phospholipids in complex with aminoglycosides, could prevent neuron-sensitive deafness in children. Accompanying the use of gentamicin and phosphogliv in the second group, there was a significant decrease in the average level of molecular peptides in the blood, and the concentration of malondialdehyde decreased 2.4 times relative to the first group (p < 0.05).
Conclusions:
Use of gentamicin with simultaneous essential phospholipids helps to reduce the amount of malondialdehyde in the blood, reduce medium-molecular peptides, and increase the activity of enzyme-protecting superoxide dismutase.
REFERENCES (20)
1.
Mahmood DH, Waters A. Comparative study of uranyl nitrate and cisplatin induced renal failure in rat. Eur J Drug Metab Pharmacol, 1994; 19: 327–36.
2.
Banday AA, Farooq N, Priyamvada S, Yusufi ANK, Khan F. Time dependent effects of gentamicin on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in rat kidney tissues. Life Sci, 2008; 82(9–10): 450–9.
3.
Khan SA, Priyamvada S, Farooq N, Khan S, Khan MW, Yusufi ANK. Protective effect of green tea extract on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. Pharmacol Res, 2009; 59: 254–62.
4.
Tietz NW. Fundamentals of Clinical Chemistry, 4th ed., W.B. Saunders Company, USA, 1996.
5.
Smith EL, Hill RL, Lehman IR, Lefkowitz RJ, Handler P, White A. Principles of Biochemistry: Mammalian Biochemistry, 7th ed., McGraw-Hill, New York, USA, 1988.
6.
Aleksandrova LA, Pospelova ML, Sorokoumov VA, Barnaulov OD. Comparative evaluation of antioxidant properties of herbal preparations. Scien App SPbGMU, 1998; 5(1): 46–50. [Aleksandrova et al., Sravnitel’naya ocenka antioksidantnyx svojstv preparatovrastitel’nogo proisxozhdeniya // Uchen. zap. SPbGMUm. I.P. Pavlova. 1998 - T.5, #1. - S.46–50.].
7.
Priyamvada S, Priyadarshini M, Arivarasu NA, Farooq N, Khan S, Khan SA, Khan MW, Yusufi AN. The protective effect of dietary fish oil on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. Prostaglandins Leukot Essent Fatty Acids, 2008; 78(6): 369–81.
8.
Altman YA, Tavartkiladze GA. Audiology Guide. Moscow: DMK “Press”, 2003 p.350. [Altman and Tavartkiladze. Rukovodstvo po audiologii. M: DMK «Press», 2003 - 350s.].
9.
Burlakova EB. Bioantioxidants. The nanoworld of weak influences “dwarfs”: its laws, commonality and differences with the world of “giants”. VIII International Conference Bioantioxidant. Moscow, 4–6 October 2010. p.69–7. [Burlakova EB. Bioantioksidanty. Nanomir slabyx vozdejstvij – «karlikov», ego zakony, obshhnost’ i razlichiya s mirom «gigantov». //VIII Mezhdunarodnaya konferenciya ioantioksidant. Tezisy dokladov, Moskva, 4–6 oktyabrya 2010, s.69–7.].
10.
Gabrielyan NI, Dmitriev AA, Kulakov GP, Mekikyan AM, Shcherbaneva OI. Diagnostic value of determining average molecules in blood plasma in nephrological diseases. Clin Med, 1981; T. LIX 10: p.38–42. [Gabriehlyan et al. Diagnosticheskaya cennost’ opredeleniya srednix molekul v plazme krovi pri nefrologicheskix zabolevaniyax // Klin Med, 1981; T. LIX # 10: S.38–42.].
11.
Dubinina EE. The role of oxidative stress in pathological conditions of the nervous system. Advances in functional neurochemistry. SPb, 2003; p.285–301. [Dubinina EE. Rol’ okislitel’nogo stressa pri patologicheskix sostoyaniyax nervnoj sistemy // Uspexi funkcional’noj nejroximii. SPb, 2003; S.285–301.].
12.
Korolyuk MA, Ivanova LI, Mayorova IG, Tokarev VF. Method for determination of catalase. Lab Case, 1988, p. 16–19. [Korolyuk et al. Metod opredeleniya katalazy. // Lab delo, 1988; S. 16–19.].
13.
Lansov AA, Anichin VF, Alibekov IM. Rationale for the use of midocalm for the prevention and treatment of sensorineural hearing loss of antibiotic etiology. Herald of Otorhinolaryngology, 1989; 5: 15–20. [Lancov et al. Obosnovanie primeneniya midokalma dlya profilaktiki i lecheniya nejrosensornoj tugouxosti antibiotikovoj ehtiologii // Vestn Otorinolaringologii,1989 #5, S.15–20.].
14.
Malyavina US, Ovchinnikov YM, Fisenko VP et al. Experience of using the drug Cavinton to prevent the development of sensorineural hearing loss in patients with various forms of tuberculosis. Herald of Otorhinolaryngology, 2003; 3:35–40. [Maljavina i /dr. Opyt primenenija preparata kavinton dlja predotvrashhenija razvitija nejrosensornoj tugouhosti u bol’nyh razlichnymi formami tuberkuleza // Vestn otorinolaringologiitorinolaringologii, 2003; #3. S.35–40.].
15.
Matsukura T, Tanaka X. Application of a complex of L-carnosine with zinc in medicine. Biochemistry, 2000; 65(7): 961–8. [Matsukura T, Tanaka X. Primenenie kompleksa L-karnozina s cinkom v medicine // Biohimija, 2000; T.65, vyp. 7: S.961–8.].
16.
Nagoev BS, Tulupova MV. Study of the prooxidant properties of blood plasma in psoriasis by the level of malondialdehyde. Clinical Laboratory Diagnostics, 2008; 8: 15–17. [Nagoev BS, Tulupova MV. Izuchenie prooksidantnyh svojstv plazmy krovi psoriazom po urovnju malonovogo dial’degida. //Klinicheskaja laboratornaja diagnostika, 2008; #8. S.15–17.].
17.
Ryndina AM, Tomchin AB, Nizova RF, Smirnov AB, Utyanova TA. Antihypoxants and hyperbaric oxygenation in the treatment of chronic sensorineural hearing loss. Vestn. Otorhinolaryngology, 1993; 3: 20–23. [Ryndina et al. Antigipoksanty i giperbaricheskaja oksigenacija v lechenii hronicheskoj nejrosensornoj tugouhosti // Vestn otorinolaringologii, 1993; #3. S.20–23.].
19.
Mirsa PH, Fridovich I. The role of superoxide anion in the antioxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem, 1972; 247(10): 3170–5.
20.
Sha SH, Schacht J. Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo: D-methionine is a potential protectant. Hear Res, 2000; 142(1-2): 34–40.
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