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REVIEW PAPER
COCHLEAR HAIR CELL REGENERATION BASED ON STEM CELLS: A SYSTEMATIC REVIEW
1
Department of Audiology, School of Health (e2s), Center for Research Rehabilitation (CiR), Polytechnic Institute of Porto (P.Porto), Portugal
2
Department of Audiology, School of Health, Istanbul Medipol University, Istanbul, Turkey
3
Department of Physics, School of Health (e2s), Polytechnic Institute of Porto (P.Porto), Portugal
4
National University of Ireland, Dublin, Ireland
A - Research concept and design; B - Collection and/or assembly of data; C - Data analysis and interpretation; D - Writing the article; E - Critical revision of the article; F - Final approval of article;
Submission date: 2023-12-05
Final revision date: 2024-07-23
Acceptance date: 2024-07-26
Publication date: 2024-09-05
Corresponding author
David Tomé
Department of Audiology, School of Health, Polytechnic Institute of Porto, Rua Dr. António Bernardino de Almeida, 400, 4200-072, Porto, Portugal
Department of Audiology, School of Health, Polytechnic Institute of Porto, Rua Dr. António Bernardino de Almeida, 400, 4200-072, Porto, Portugal
J Hear Sci 2024;14(3):19-36
KEYWORDS
TOPICS
ABSTRACT
Introduction:
According to the World Health Organization (WHO), by 2050 at least 700 million people will need access to hearing care and hearing rehabilitation services. The search for cell or gene therapies has been intensifying, and stem cell therapy looks a promising candidate to support hearing regeneration and reduce these numbers. The aim of this study is to provide an overview of current advances in stem cellbased therapies for cochlear hair cell regeneration and the processes being developed for future applicability.
Material and methods:
Identification and review of all articles in the databases PubMed, Web of Science, and PLoS One using the terms stem cell, auditory hair cell regeneration, and mammalian during February 2023 and following the PRISMA guidelines.
Results:
50 articles were obtained, published between 2003 and 2022 and were systematically analyzed. The current research quantity is limited and further studies are needed, particularly in human tissue.
Conclusions:
The simultaneous use of cell therapy and gene therapy may lead to more promising results. Moreover, advances in cochlear hair cell regeneration with stem cells suggest there is a realistic potential to make the technique a useful future therapy.
According to the World Health Organization (WHO), by 2050 at least 700 million people will need access to hearing care and hearing rehabilitation services. The search for cell or gene therapies has been intensifying, and stem cell therapy looks a promising candidate to support hearing regeneration and reduce these numbers. The aim of this study is to provide an overview of current advances in stem cellbased therapies for cochlear hair cell regeneration and the processes being developed for future applicability.
Material and methods:
Identification and review of all articles in the databases PubMed, Web of Science, and PLoS One using the terms stem cell, auditory hair cell regeneration, and mammalian during February 2023 and following the PRISMA guidelines.
Results:
50 articles were obtained, published between 2003 and 2022 and were systematically analyzed. The current research quantity is limited and further studies are needed, particularly in human tissue.
Conclusions:
The simultaneous use of cell therapy and gene therapy may lead to more promising results. Moreover, advances in cochlear hair cell regeneration with stem cells suggest there is a realistic potential to make the technique a useful future therapy.
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